Sustainability Report 2014 Lek d.d.

Sustainability Report 2014 – Lek d.d. Environment 38 From our own pumping station (000 m 3 ) 1,591 1,432 1,335 1,376 1,480 From the public water supply network (000 m 3 ) 94 77 80 81 83 From our own pumping station (000 m 3 ) 1,384 1,325 1,228 1,297 1,340 From the public water supply network (000 m 3 ) 46 39 61 58 58 Menge‰ Lendava 2010 2010 2011 2011 2013 2013 2012 2012 2014 2014 Table 10: Water supply quantities and sources at the Menge‰ and Lendava sites in 000 m 3 2.4.3 Recycling and reuse 46 Recycled water is mostly reused for the cooling of proc- esses, mainly at the Menge‰ site. The share of recycled water, however, is on the increase at other sites as well. At the Menge‰ site, a three-level cooling water system oper- ating at different temperature regimes enables the water from one system to be fed into a higher-temperature system, while a portion of water (spill) is discharged into the sew- age system. The quantities of reused water vary greatly and depend on individual processes, so they cannot be accurately calculated on the basis of the existing data capture method. Based on relevant calculations, it has been assessed that almost the entire cooling water volume is reused at least twice. At the Lendava site, the project of fermentation production expansion by installing two additional fermentation vessels was performed using the best available techniques (BAT). As the cooling cycles are of the closed-loop type, the consum- ption of well cooling water does not increase despite the increased production volume. 46 GRI Indictor G4-EN10 47 EMAS Core Indicator, GRI Indicator G4-EN23, G4-DMA 2.5.1 Waste management 47 Due to a changed data collection methodology (see Item 1.4.1), changes in the volumes of waste for the previous year occurred in 2014. Consequently, a comparison of waste volumes generated in 2011 and 2012 with the volumes in the previous years is not entirely appropriate. The data for 2011 and 2012, however, is comparable in consideration of the fact that mycelium waste is no longer incinerated in our incineration plant, and consequently became the subject of reporting in 2012 and 2013. Mycelium waste accounts for more than 97% of all waste at the Lendava site and 73% of the total waste from the entire operation of Lek, a Sandoz company. The major part of the mycelium waste is water therefore we are investigating the possibility of centrifuging the waste before being removed to a biogas plant. This would reduce the volume of waste and save on fuel consumption for transport (and consequently reduce CO 2 emissions as well). As recommended by Novartis, sewage sludge from the Lendava Wastewater Treatment Plant has been added to other Lendava site waste – the data was corrected also for all previous years. Because of two technologically different forms of production (bio-fermentative production of active ingredients and pack- aging of finished dosage forms), the Lendava production site faces different types and quantities of waste. By changing the product range, major quantitative fluctuations occur in packaging. At the Menge‰ site, more than 80% of the total waste is accounted for as hazardous waste, particularly liquid waste solvents and solid hazardous waste. One portion of this waste is reused as an energy source. The remaining quan- tity is released to authorized companies for environmentally acceptable disposal. Despite increasing production outputs, changes in the pro- duction structure and the rising number of employees, the relative quantities of non-hazardous waste have remained at almost the same level over the past 5 years. For all quantitative data presented below it applies, as al- ready mentioned, that since 2011, only data for the volume of waste released for treatment outside the production site, has been reported. 2.5 Waste Prevalje Lek (skupaj)

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