Sustainability Report 2014 Lek d.d.

Sustainability Report 2014 – Lek d.d. Environment 32 39 EMAS Core Indicator, GRI G4-EN5 The change in blister dimension for the product containing levetiracetam active ingredient Old form of packaging New form of packaging • 60% reduction of blister surface 2.2.5 Water consumption and energy efficiency Previously mentioned fluctuations resulting from the changes in production volume and structure, are also the major cause of absolute and relative variations in the energy and water consumption at individual sites. As the production outputs of a single product or a small number of products at the Lendava and Prevalje sites are relatively stable, a year-on- -year comparison of water and energy use efficiency pro- vides a true picture of trends recorded at these two sites. Major variations in the specific use of water and energy re- sources recorded at the Ljubljana and Menge‰ sites are due to the versatility of the sites’ portfolios. The manufacture of individual products at the mentioned sites is subject to major market fluctuations. Performance indexes for the Lendava site do not provide a true picture as only the production outputs by the Lendava production site are included in reporting. The operations of the other unit, the Lendava Packaging Center, however, are not included as they are not considered as production of finished products in 2014. Lendava is still the best example of continuous reduction of energy consumption per unit of product due to the uniform production portfolio over a longer period of time. As shown in Table 4, energy consumption per tonne of product was redu- ced by 739 GJ or 33% at the Lendava site in the period 2010 – 2014. If realized production of the Lendava Packaging Center was also included, the reduction would be even greater. The efficient energy consumption per tonne of product at the entire Lek level increased by 93 GJ or 27% in the same period. * Due to the improved method for acquiring data on the realization of various finished pharmaceutical products manufacture and on the mass flows of raw materials at the Ljubljana site, there was a change in the data for previous years. 2010 GJ/t 2,240 197* 720 66 348* 2011 GJ/t 2,004 185* 677 53 307* 2012 GJ/t 1,697 190* 613 56 302 2013 GJ/t 1,577 191* 645 56 299* 2014 GJ/t 1,501 164 632 46 255 Year Unit Lendava Ljubljana* Prevalje Lek (Total)* Menge‰ Table 4: Efficiency of energy resource use per unit of product 39