Sustainability Report 2014 Lek d.d.

31 Environment 37 EMAS Core Indicator 38 GRI G4-DMA 2.2.3 Efficiency of materials The graphic display of the efficiency of the use of all the raw materials at Lek d.d. reflects the intensive efforts to re- duce the consumption of raw materials per unit of product. The quantity of raw materials used per tonne of API/product has been decreasing for a number of years. In 2014, we in- creased the efficiency of the use of materials by more than 7% compared to the previous year and in the 2010–2014 period by more than 17%. The increasing efficiency of the use of materials is demonstrated in Graph 2. Due to the extensive range of active ingredients and pro- ducts, and as a result of changes to the product portfolio, the efficiency of the use of raw materials at the Ljubljana and Menge‰ site is less obvious in the graph. For this purpose, an overview by product would be required. Efficiency of the use of raw materials strongly depends on the range of pro- ducts manufactured at the Menge‰ site, where the raw ma- terials are integrated into the product only to a minor extent and are mostly used in the manufacture process of a fin- ished product. By reviewing the method for acquiring data on the realizati- on of finished pharmaceutical products at the Ljubljana site, we improved the accuracy of the data on the efficiency of the use of raw materials in 2014. Graph 2: Efficacy of the use of various materials per unit of product 37 – by site and total Lendava Lek d.d. Ljubljana Menge‰ Prevalje Efficacy of the use of raw materials per unit of product Efficacy of the use of raw materials - total 40 10 50 12 2010 2010 30 8 20 6 10 2 4 0 0 t/t t/t Year Year 2011 2011 2012 2012 2013 2013 2014 2014 2.2.4 Sustainable packaging approach 38 The two production sites manufacturing finished dosage forms are the major consumers of packaging material: Ljubljana with 63% and Prevalje with 33%. At the Menge‰ and Lendava sites packaging consumption accounts for less than 4% of the total packaging consumption of Lek, a Sandoz company. In accordance with the Novartis’ policy of sustainable use of the packaging and binding waste management hierarchy, we defined the basic principles of packaging design and production: • Selection of materials: - Using materials of lower environmental impact (naturally light materials, recycling-based materials, recyclable materials from renewable sources that contain no toxic ingredients), - Using a small number of various materials that have to be recyclable. • Packaging shaping and size: - Reducing the total weight of materials (thinner and lighter materials), - Reducing the volume (reduced environmental impact of transport), - Reducing the number of packaging types (including integration of primary and secondary packaging into one, uniform packaging to meet various customer needs). • Ordering packaging materials: - Cooperation with environmentally and socially re- sponsible suppliers, - Using exclusively environmentally certified/recom- mended materials (e.g. non-chlorine bleached paper, certified cotton ...), - Cooperation with local/regional packaging suppliers (lower environmental impact of transport). Results of improvements in 2014 • By optimizing packaging of the product containing ra- beprazol, rosuvastatin, ranital or candesartan we redu- ced the blister surface, volume and packaging weight. • In the product containing levetiracetam we replaced blisters by plastic bottles thereby reducing the blister volume by 60%. The number of packs per pallet was increased by the same proportion, resulting in environ- mentally more optimal use of transport due to lower fuel consumption and less CO 2 emissions. • We abolished patient information leaflets for products in the US market and hired contractors to inform pharmacists about the availability of package leaflets in electronic form. Patient information leaflets are now constantly updated while prior to that the updates reached the pharmacists only on receipt of the new shipment of medicines.